CLOSINGS: View Closings

U.S. recommends 'pause' in use of J&J vaccine over blood clot reports

FILE - In this Thursday, April 8, 2021 file photo, the Johnson & Johnson COVID-19 vaccine sits on a table at a pop up vaccinations site the Albanian Islamic Cultural Center, in the Staten Island borough of New York. The U.S. is recommending a “pause” in a
FILE - In this Thursday, April 8, 2021 file photo, the Johnson & Johnson COVID-19 vaccine sits on a table at a pop up vaccinations site the Albanian Islamic Cultural Center, in the Staten Island borough of New York. The U.S. is recommending a “pause” in a

Six women suffered blood clots within two weeks of vaccination.

Posted: Apr 13, 2021 7:07 AM
Updated: Apr 13, 2021 1:00 PM

WASHINGTON (AP) — The U.S. on Tuesday recommended a “pause” in using the single-dose Johnson & Johnson COVID-19 vaccine to investigate reports of rare but potentially dangerous blood clots, setting off a chain reaction worldwide and dealing a setback to the global vaccine campaign.

The Centers for Disease Control and Prevention and the Food and Drug Administration announced that they were investigating unusual clots that occurred 6 to 13 days after vaccination. The acting FDA commissioner said she expected the pause to last a matter of days.

The decision triggered swift action in Europe and elsewhere as the drugmaker and regulators moved to halt the use of the J&J vaccine, at least for now. Hundreds of thousands of doses of the vaccine were due to arrive in European countries this week. The European Union has been plagued by supply shortages, logistical problems and concerns over unusual blood clots in a small number of people who received the AstraZeneca vaccine.

Any slowdown in the dissemination of the shots could have broad implications for the global vaccination effort. The J&J vaccine held immense promise because its single-dose regimen and relatively simple storage requirements would make it easier to use, especially in less affluent countries.

The clots occurred in veins that drain blood from the brain and occurred together with low platelets, the fragments in blood that normally form clots. All six cases were in women between the ages of 18 and 48. One person died, and all of the cases remain under investigation.

More than 6.8 million doses of the J&J vaccine have been given in the U.S., the vast majority with no or mild side effects.

The FDA said the cases under investigation appear similar to the clots that European authorities say are possibly linked to the AstraZeneca vaccine, which is not yet cleared in the U.S. European regulators have stressed that the AstraZeneca risk appears to be lower than the possibility of developing clots from birth control pills.

Federally run mass vaccination sites will pause the use of the J&J shot, and states and other providers are expected to follow. But authorities stressed they have found no signals of clot problems with the most widely used COVID-19 vaccines in the U.S. — from Moderna and Pfizer.

“I’d like to stress these events appear to be extremely rare. However COVID-19 vaccine safety is a top priority,” acting FDA Commissioner Janet Woodcock said at a news conference.

Speaking at a White House news conference, Dr. Anthony Fauci, the nation's top expert on infectious disease, said the pause would allow the FDA and the CDC to investigate the clotting cases "to try and understand some of the mechanisms” and “to make physicians more aware of this.”

A CDC committee will meet Wednesday to discuss the cases, and the FDA has also launched an investigation into the cause of the clots and low platelet counts.

FDA officials emphasized that Tuesday’s action was not a mandate. Doctors and patients could still use J&J’s vaccine if they decide its benefits outweigh its risks for individual cases, said Dr. Peter Marks.

The agencies recommend that people who were given the J&J vaccine should contact their doctor is they experience severe headache, abdominal pain, leg pain, or shortness of breath within three weeks.

J&J said in a statement that it was aware of the reports of blood clots, but that no link to its vaccine had been established. The company also said it would delay the rollout of its vaccine in Europe as a precaution.

U.S. health authorities cautioned doctors against using a typical clot treatment, the blood-thinner heparin. “In this setting, administration of heparin may be dangerous and alternative treatments need to be given,” the FDA and CDC said.

European authorities investigating the AstraZeneca cases have concluded clots appear to be similar to a very rare abnormal immune response that sometimes strikes people treated with heparin, leading to a temporary clotting disorder.

While it's not clear yet if the reports among J&J recipients are related, doctors would treat these kinds of unusual clots like they treat people who have the heparin reaction — with different kinds of blood thinners and sometimes an antibody infusion, said Dr. Geoffrey Barnes, a clot expert at the University of Michigan.

Even without J&J’s vaccine, White House officials said they remain on track to have enough supplies to vaccinate most American adults by the summer.

“We believe there’s enough vaccine in the system — Moderna and Pfizer — for all Americans who want to get vaccinated by May 31 to do so,” said Jeff Zients, the White House’s COVID-19 response coordinator.

Asked if the government was overreacting to six cases out of more than 6 million vaccinations, the CDC’s Dr. Anne Schuchat said recommendations will come quickly.

Because these unusual clots require special treatment, “it was of the utmost importance to us to get the word out,” she said. “That said, the pandemic is quite severe and cases are increasing in lots of places and vaccination’s critical.”

States and cities swiftly moved to implement the pause. New York state Health Commissioner Dr. Howard Zucker said people with Tuesday appointments for J&J vaccines at state-run mass vaccination clinics will instead get the Pfizer vaccine.

The city of Dallas had planned to begin an in-home vaccination program using the J&J vaccine for homebound or elderly people. The city said it will pause the program until more guidance is released.

The J&J vaccine received emergency use authorization from the FDA in late February with great fanfare. Yet the shot only makes up a small fraction of the doses administered in the U.S. J&J has been plagued by production delays and manufacturing errors at the Baltimore plant of a contractor.

Last week, the drugmaker took over the facility to scale up production in hopes of meeting its commitment to the U.S. government of providing about 100 million doses by the end of May.

Only about 9 million of the company's doses have been delivered to states and are awaiting administration, according to CDC data.

The European Medicines Agency stressed that the benefits of receiving the vaccine outweigh the risks for most people. But several countries have imposed limits on who can receive the vaccine. Britain recommended that people under 30 be offered alternatives.

But the J&J and AstraZeneca vaccines are made with the same technology. Leading COVID-19 vaccines train the body to recognize the spike protein that coats the outer surface of the coronavirus. But the J&J and AstraZeneca vaccines use a cold virus, called an adenovirus, to carry the spike gene into the body. J&J uses a human adenovirus to create its vaccine while AstraZeneca uses a chimpanzee version.

U.S. stock markets initially dropped on the J&J news, but some indices were up slightly by late morning. Johnson & Johnson shares were down nearly 3 percent, an unusually big drop for the drug giant, with more shares changing hands in the first two hours than on an average day.

Minnesota Coronavirus Cases

Data is updated nightly.

Cases: 592750

Reported Deaths: 7376
CountyCasesDeaths
Hennepin1226641731
Ramsey51369875
Dakota45906452
Anoka41713438
Washington26899283
Stearns22238222
St. Louis17758304
Scott17275124
Wright16034140
Olmsted1324298
Sherburne1170887
Carver1049145
Clay815792
Rice8056107
Blue Earth750441
Crow Wing665089
Kandiyohi655783
Chisago599751
Otter Tail574978
Benton570297
Goodhue478072
Douglas467875
Mower465732
Winona454550
Itasca437556
McLeod423659
Isanti421364
Morrison419260
Nobles407748
Beltrami395559
Steele388315
Polk384168
Becker380253
Lyon360651
Carlton345254
Freeborn341729
Pine328622
Nicollet326143
Brown305440
Mille Lacs304553
Le Sueur291723
Todd282132
Cass272828
Meeker256340
Waseca236222
Martin230632
Roseau209019
Wabasha20533
Hubbard189341
Dodge18493
Renville180243
Redwood174337
Houston171816
Cottonwood164923
Fillmore156310
Wadena155922
Pennington153619
Faribault152319
Chippewa152238
Kanabec144626
Sibley143510
Aitkin134936
Watonwan13279
Rock128219
Jackson121812
Pipestone115426
Yellow Medicine114120
Pope11026
Murray10639
Swift105218
Stevens91311
Marshall88117
Clearwater86816
Koochiching83315
Wilkin81512
Lake81119
Lac qui Parle75322
Big Stone6004
Lincoln5813
Grant5768
Mahnomen5499
Norman5399
Unassigned50093
Kittson48622
Red Lake3967
Traverse3705
Lake of the Woods3253
Cook1640

Iowa Coronavirus Cases

Data is updated nightly.

Cases: 367061

Reported Deaths: 5938
CountyCasesDeaths
Polk57642625
Linn20869335
Scott20044241
Black Hawk15813308
Woodbury15132228
Johnson1448383
Dubuque13374208
Dallas1118298
Pottawattamie11122168
Story1061748
Warren577988
Clinton555693
Cerro Gordo540389
Sioux514474
Webster512293
Marshall483075
Muscatine481199
Des Moines457166
Wapello4301122
Buena Vista424840
Jasper419272
Plymouth401280
Lee375855
Marion362575
Jones298957
Henry291837
Carroll285952
Bremer284560
Crawford266140
Boone264834
Benton256655
Washington253750
Dickinson248443
Mahaska230351
Jackson222142
Clay215625
Kossuth215364
Tama209771
Delaware209641
Winneshiek196934
Page192722
Buchanan191332
Cedar190023
Hardin185643
Fayette185141
Wright184637
Hamilton179949
Harrison179673
Clayton169556
Butler164934
Madison162319
Mills162222
Floyd160942
Cherokee158938
Lyon158041
Poweshiek154734
Allamakee151451
Iowa148824
Hancock148234
Winnebago142431
Calhoun138513
Cass138554
Grundy136333
Emmet134340
Jefferson132435
Shelby131037
Sac130319
Union128333
Louisa128149
Appanoose127949
Mitchell126342
Chickasaw124116
Guthrie121530
Franklin120521
Humboldt119126
Palo Alto112823
Howard104622
Montgomery103338
Clarke100124
Unassigned9740
Keokuk95931
Monroe95129
Ida90335
Adair86532
Pocahontas85522
Davis83024
Monona82730
Osceola78716
Greene77710
Lucas77223
Worth7478
Taylor66012
Fremont6229
Decatur6089
Ringgold55824
Van Buren55818
Wayne53923
Audubon51010
Adams3384
Rochester
Partly Cloudy
58° wxIcon
Hi: 69° Lo: 51°
Feels Like: 58°
Mason City
Partly Cloudy
61° wxIcon
Hi: 73° Lo: 46°
Feels Like: 61°
Albert Lea
Partly Cloudy
57° wxIcon
Hi: 74° Lo: 47°
Feels Like: 57°
Austin
Partly Cloudy
59° wxIcon
Hi: 72° Lo: 49°
Feels Like: 59°
Charles City
Mostly Cloudy
° wxIcon
Hi: 72° Lo: 49°
Feels Like: °
Warmer conditions for the weekend
KIMT Radar
KIMT Eye in the sky

Community Events