No. 12 Iowa State can ensure a spot in the Big 12 championship game with a home win over West Virginia.
The Cyclones are home against West Virginia on Saturday.
They are also in the title game if No. 13 Oklahoma, No. 19 Oklahoma State or Kansas State lose.
Iowa State has never played in any conference title game. Five-time defending Big 12 champion Oklahoma is more than a three-touchdown favorite at home against Baylor.
Oklahoma State plays at TCU, which has won three of its last four games. West Virginia's final two regular-season games are against the Cyclones and Sooners.