First COVID-19 vaccine tested in US poised for final testing

Early-stage testing showed the first COVID-19 vaccine tested in the U.S. revved up people’s immune systems the way scientists had hoped.

Posted: Jul 14, 2020 4:25 PM
Updated: Jul 14, 2020 8:15 PM

The first COVID-19 vaccine tested in the U.S. revved up people’s immune systems just the way scientists had hoped, researchers reported Tuesday -- as the shots are poised to begin key final testing.

“No matter how you slice this, this is good news,” Dr. Anthony Fauci, the U.S. government’s top infectious disease expert, told The Associated Press.

The experimental vaccine, developed by Fauci’s colleagues at the National Institutes of Health and Moderna Inc., will start its most important step around July 27: A 30,000-person study to prove if the shots really are strong enough to protect against the coronavirus.

But Tuesday, researchers reported anxiously awaited findings from the first 45 volunteers who rolled up their sleeves back in March. Sure enough, the vaccine provided a hoped-for immune boost.

Those early volunteers developed what are called neutralizing antibodies in their bloodstream -- molecules key to blocking infection -- at levels comparable to those found in people who survived COVID-19, the research team reported in the New England Journal of Medicine.

“This is an essential building block that is needed to move forward with the trials that could actually determine whether the vaccine does protect against infection,” said Dr. Lisa Jackson of the Kaiser Permanente Washington Research Institute in Seattle, who led the study.

There’s no guarantee but the government hopes to have results around the end of the year -- record-setting speed for developing a vaccine.

The vaccine requires two doses, a month apart.

There were no serious side effects. But more than half the study participants reported flu-like reactions to the shots that aren’t uncommon with other vaccines -- fatigue, headache, chills, fever and pain at the injection site. For three participants given the highest dose, those reactions were more severe; that dose isn’t being pursued.

Some of those reactions are similar to coronavirus symptoms but they’re temporary, lasting about a day and occur right after vaccination, researchers noted.

“Small price to pay for protection against COVID,” said Dr. William Schaffner of Vanderbilt University Medical Center, a vaccine expert who wasn’t involved with the study.

He called the early results “a good first step,” and is optimistic that final testing could deliver answers about whether it's really safe and effective by the beginning of next year.

“It would be wonderful. But that assumes everything’s working right on schedule,” Schaffner cautioned.

Moderna’s share price jumped nearly 15 percent in trading after U.S. markets closed. Shares of the company, based in Cambridge, Massachusetts, have nearly quadrupled this year.

Tuesday's results only included younger adults. The first-step testing later was expanded to include dozens of older adults, the age group most at risk from COVID-19. Those results aren't public yet but regulators are evaluating them. Fauci said final testing will include older adults, as well as people with chronic health conditions that make them more vulnerable to the virus — and Black and Latino populations likewise affected.

Nearly two dozen possible COVID-19 vaccines are in various stages of testing around the world. Candidates from China and Britain’s Oxford University also are entering final testing stages.

The 30,000-person study will mark the world’s largest study of a potential COVID-19 vaccine so far. And the NIH-developed shot isn’t the only one set for such massive U.S. testing, crucial to spot rare side effects. The government plans similar large studies of the Oxford candidate and another by Johnson & Johnson; separately, Pfizer Inc. is planning its own huge study.

Already, people can start signing up to volunteer for the different studies.

People think “this is a race for one winner. Me, I’m cheering every one of them on,” said Fauci, who directs NIH’s National Institute of Allergy and Infectious Diseases.

“We need multiple vaccines. We need vaccines for the world, not only for our own country.”

Around the world, governments are investing in stockpiles of hundreds of millions of doses of the different candidates, in hopes of speedily starting inoculations if any are proven to work.

Scroll for more content...

Minnesota Coronavirus Cases

Data is updated nightly.

Confirmed Cases: 90942

Reported Deaths: 2021
CountyConfirmedDeaths
Hennepin26054922
Ramsey10572318
Dakota7216125
Anoka5801132
Stearns381223
Washington361055
Scott245833
Olmsted231927
Nobles193616
Blue Earth16116
Wright15407
St. Louis140034
Carver13607
Rice13088
Mower12935
Clay128140
Sherburne110414
Kandiyohi9332
Winona85218
Lyon6524
Waseca5338
Freeborn5223
Steele5222
Benton5153
Watonwan5064
Nicollet50416
Todd4792
Chisago4581
McLeod4522
Le Sueur4454
Crow Wing43918
Otter Tail4004
Beltrami3795
Goodhue3329
Martin3299
Pine2840
Itasca28213
Polk2754
Isanti2650
Douglas2622
Becker2482
Carlton2451
Cottonwood2190
Pipestone2159
Unassigned21252
Morrison2081
Dodge2020
Chippewa1971
Sibley1843
Meeker1832
Brown1802
Wabasha1800
Yellow Medicine1622
Murray1572
Rock1550
Mille Lacs1503
Redwood1420
Renville1367
Jackson1341
Faribault1320
Cass1313
Swift1231
Roseau1170
Houston1140
Pennington1121
Fillmore1110
Koochiching1113
Kanabec1098
Lincoln1020
Stevens931
Pope890
Hubbard830
Aitkin731
Big Stone700
Wadena670
Grant594
Lake570
Wilkin563
Norman520
Marshall501
Lac qui Parle470
Mahnomen461
Red Lake390
Traverse300
Clearwater260
Lake of the Woods211
Kittson120
Cook60

Iowa Coronavirus Cases

Data is updated nightly.

Confirmed Cases: 80698

Reported Deaths: 1275
CountyConfirmedDeaths
Polk15366259
Woodbury504263
Johnson501127
Black Hawk437586
Linn3808108
Story331517
Dubuque282341
Scott281827
Dallas269838
Pottawattamie200238
Buena Vista195112
Marshall176234
Sioux13723
Wapello127157
Webster120214
Clinton107419
Muscatine106854
Plymouth105820
Crawford10145
Cerro Gordo100221
Warren9326
Jasper77232
Des Moines7407
Marion7265
Tama69431
Carroll6375
Henry6204
Lee5997
Wright5631
Dickinson4876
Boone4788
Bremer4687
Washington43211
Louisa42515
Mahaska34619
Delaware3423
Franklin34218
Hamilton3153
Jackson3043
Floyd3023
Winneshiek2995
Clay2963
Benton2871
Hardin2841
Winnebago27511
Butler2622
Lyon2603
Clarke2563
Emmet25210
Poweshiek2528
Buchanan2511
Allamakee2486
Jones2483
Shelby2441
Clayton2343
Guthrie2315
Kossuth2310
Cedar2231
Chickasaw2220
Sac2200
Grundy2062
Madison2062
Cherokee2042
Fayette2002
Iowa1921
Mitchell1830
Howard1826
Harrison1812
Humboldt1763
Hancock1742
Calhoun1722
Mills1691
Palo Alto1630
Pocahontas1542
Lucas1526
Monroe15010
Page1420
Monona1401
Cass1362
Jefferson1341
Osceola1300
Appanoose1253
Taylor1241
Union1223
Davis1164
Van Buren1111
Ida1030
Worth1030
Keokuk911
Fremont900
Greene890
Montgomery885
Wayne842
Audubon681
Adair671
Decatur600
Ringgold442
Adams290
Unassigned70
Rochester
Clear
58° wxIcon
Hi: 81° Lo: 55°
Feels Like: 58°
Mason City
Clear
57° wxIcon
Hi: 81° Lo: 53°
Feels Like: 57°
Albert Lea
Clear
66° wxIcon
Hi: 81° Lo: 55°
Feels Like: 66°
Austin
Clear
64° wxIcon
Hi: 81° Lo: 54°
Feels Like: 64°
Charles City
Clear
61° wxIcon
Hi: 81° Lo: 52°
Feels Like: 61°
Tracking more warmth before cooler weather arrives for the weekend
KIMT Radar
KIMT Eye in the sky

Latest Video

Image

HyVee gives away 500 meals

Image

NIACC dealing with Covid-19 on a daily basis

Image

MN Statehouse candidates meet in forum

Image

Iowa voter registration day

Image

Tuesday's soccer highlights

Image

Trump sign getting looks in cornfield

Image

Sara's Evening Forecast - Tuesday

Image

Antibody Testing for blood donors

Image

Rochester going electric with public transport

Image

National Voter Registration Day

Community Events