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Coronavirus vaccines: Your questions answered

The Moderna vaccine is 94.5% effective against coronavirus, according to early data released by the company, making it the second vaccine in the United States to have a stunningly high success rate. The company's Chief Medical Officer, Dr. Tal Zaks, speaks to CNN's Elizabeth Cohen.

Posted: Nov 16, 2020 11:10 PM
Updated: Nov 16, 2020 11:10 PM

There is sorely needed good news on the vaccine front: A second US vaccine has been found to have a high success rate against Covid-19. Moderna announced on Monday that its vaccine was 94.5% effective against coronavirus, according to early data.

Vaccinations could begin in the United States in the second half of December, starting with high-risk groups and becoming available for the rest of the population in spring, according to Dr. Anthony Fauci, director of the National Institute of Allergy and Infectious Diseases.

Here are some answers to common questions about the coronavirus vaccines being developed to prevent Covid-19.

Don't vaccines take years to develop safely? How have these two been developed in just 10 months?

Most vaccines in use today have taken years and, in some cases, decades to develop, but governments have poured huge amounts of money into companies and institutions developing vaccines, with initiatives like Operation Warp Speed in the United States and the Vaccine Taskforce in the United Kingdom.

The pandemic has galvanized the scientific community all around the world, with groups of researchers in dozens of countries on a fast-paced hunt to understand how the virus works.

Operation Warp Speed has also drawn up protocols to allow trials to proceed more quickly, and industrial-scale manufacturing of the vaccines has taken place before we knew whether they would be effective. This means we have millions of doses ready to be used.

How effective is this vaccine?

The vaccine developed by Pfizer, which announced its early successful results last week, and Moderna's are both more than 90% effective, according to the early data, a higher rate than many vaccines for other diseases. However, the results are extremely preliminary and aren't what health authorities will use to authorize vaccines.

In Moderna's trial, 15,000 study participants were given a placebo, which is a shot of saline that has no effect. Over several months, 90 of those people developed Covid-19. Another 15,000 participants were given the vaccine, and five of them developed Covid-19.

Among those receiving a placebo, 11 became severely ill, but none of the participants who received the vaccine became severely ill.

The head of the International Vaccine Institute has hailed biotech company Moderna's early data on its Covid-19 vaccine candidate, saying it is "proof of concept," but cautioned that it's still early days in terms of follow-up efficacy.

"I think it's really great news and in a way confirmation that the RNA vaccines are able to protect against infectious disease and it is also a good example again that Covid vaccines are a possibility," Dr. Jerome Kim, the institute's director general, told CNN on Monday.

"It will be really important to know what efficacy is - not at two months, but at six and twelve," Kim said.

There are still lots of unknowns about how the new coronavirus vaccines would work in practice. It's not clear whether they would prevent infection altogether or make severe illness less likely. Doctors also do not know how long their protection will last.

However, Fauci described it "as good as it gets." He had said previously he would settle for a vaccine that was 70% to 75% effective.

Vaccines have various efficacy rates. According to the US Centers for Disease Control and Prevention, a full round of polio vaccines is 99% to 100% effective; full vaccination against diphtheria, tetanus and pertussis is 80% to 90% effective, while the efficacy of flu vaccine varies from year to year.

How safe are the vaccines, and are there any side effects?

Moderna said its vaccine did not have any significant side effects. A small percentage of those who received it experienced symptoms such as body aches and headaches. It's similar to what people might experience after a flu shot and is a sign the vaccine is working to create an immune defense.

"They report no safety concerns - the main side effects are injection site pain, fatigue, muscle or joint aches and pains and headache which seemed to occur more frequently after the second injection," Dr. Penny Ward, a visiting professor in pharmaceutical medicine at King's College London, told the SMC.

"Clearly we still need to see the complete scientific details in a publication to be able to judge the outcomes independently."

After a vaccine is approved for emergency use authorization in the US, the CDC will continue to monitor side effects and assess whether any are a safety concern that warrants a change in recommendation.

How do these vaccines work? I'm worried they sound experimental.

Vaccines typically mimic part of the virus they protect against, prompting a response from your immune system.

The vaccines from Moderna and Pfizer both use a new approach that hasn't resulted in an approved vaccine before -- although they have been studied in clinical trials for other viruses.

The two vaccines use genetic code rather than any part of the virus itself, with a technique called messenger RNA, or mRNA. The vaccines deliver mRNA, which is a genetic recipe. In this case, the genetic recipe directs cells to make pieces of the spikes that sit atop the coronavirus. Once it's injected, the body's immune system makes antibodies that recognize these spikes. If a vaccinated person is later exposed to the coronavirus, those antibodies should stand at the ready to attack the virus.

The fact that Moderna and Pfizer have independently produced very similar results using the same technique is a vote of confidence in the genetic technology, experts said, and their results could make it much easier and quicker to produce other vaccines.

"Using this technology, vaccine candidates can be produced substantially faster in the future to combat virtually any infectious disease, by producing vaccines against both existing pathogens and future, currently unknown pathogens," Zoltán Kis, research associate at the Future Vaccine Manufacturing Hub, Imperial College London, told the SMC.

Other companies are developing vaccines using other techniques -- the Oxford/AstraZeneca vaccine is made from a harmless modified chimpanzee virus, while the traditional route is to use the inactivated virus.

Sign me up! When can I get it?

While Fauci said he expects the first Covid-19 vaccinations to begin toward the latter part of December, initially there won't be enough vaccine for everyone. The highest-priority groups, which include health care workers, the elderly and people with underlying medical conditions, will get the vaccine first.

"I think that everybody else will start to get vaccinated towards the end of April," Fauci said. "And that will go into May, June, July. It will take a couple of months to do."

The British government has asked the National Health Service, known as NHS, to be ready to deploy a vaccine from the beginning of December.

What if I'm old, pregnant or clinically vulnerable?

Among the 30,000 participants in the Moderna trial, more than 7,000 Americans were over the age of 65, the company said. It also included more than 5,000 Americans who are under the age of 65 but who have high-risk chronic diseases that put them at increased risk of severe Covid-19, such as diabetes, severe obesity and cardiac disease.

The study also includes more than 11,000 participants from communities of color, representing 37% of the study population, which Moderna said was similar to the diversity of the US population. This includes more than 6,000 participants who identify as Hispanic or Latinx, and more than 3,000 participants who identify as Black or African American.

Noubar Afeyan, the co-founder and chairman of Moderna, said the company doesn't see "any difference in the results," among the subgroups in its Covid-19 vaccine trials.

"Moderna actually slightly slowed down the trial recruitment to ensure that we had a substantial representation, and it turns out, 37% of our trials were people, were subjects, that are considered of color," Afeyan said on CNN International Monday.

"Generally, it looks like the vaccine performs broadly across all the population groups," Afeyan said.

However, we don't know anything about groups not involved in the trial such as children or pregnant women.

"Urgent questions remain to be answered, including how long these vaccines will be effective for and whether these vaccines work across different populations, in all age groups, ethnicities, and those with prior health conditions," said Charlie Weller, head of vaccines at medical research charity Wellcome.

"Only upon trial completion will we be able to assess the full efficacy and safety of any vaccine candidate."

Will the vaccines be compulsory? What happens if I decide not to get vaccinated?

Some people will see it as their patriotic duty to get vaccinated, but others may not. The UK has said it won't make it compulsory, and Fauci has said that getting the vaccine likely won't be mandatory.

If you decide against getting a vaccination, it does have wider implications. Not only will you not have protection against Covid-19, but it could potentially make it harder to achieve community, or herd, immunity. This protects high-risk groups that might not be able to get the vaccination.

It is estimated that a Covid-19 vaccine will need to be accepted by at least 55% of the population to provide community immunity, according to the London School of Hygiene & Tropical Medicine, and some scientists anticipate even higher numbers will be needed.

Minnesota Coronavirus Cases

Data is updated nightly.

Cases: 560450

Reported Deaths: 7122
CountyCasesDeaths
Hennepin1167211690
Ramsey48313858
Dakota42928423
Anoka38965419
Washington25195274
Stearns21198219
St. Louis16926298
Scott16187118
Wright14964128
Olmsted1282897
Sherburne1072580
Carver993045
Clay787390
Rice7701102
Blue Earth704240
Kandiyohi631381
Crow Wing624286
Chisago554750
Otter Tail547673
Benton536697
Mower453032
Goodhue448572
Douglas446071
Winona439549
Nobles401948
Morrison397559
McLeod397255
Isanti382559
Itasca379053
Beltrami375457
Polk367967
Steele366214
Becker359448
Lyon349748
Carlton331152
Freeborn329629
Pine313821
Nicollet310343
Brown295639
Mille Lacs285450
Le Sueur273822
Todd270030
Cass252526
Meeker239137
Waseca231921
Martin215230
Wabasha20003
Roseau198319
Hubbard174441
Renville172943
Dodge17253
Redwood166735
Houston162714
Cottonwood158221
Fillmore15229
Pennington151519
Chippewa147537
Wadena145821
Faribault145519
Sibley137110
Kanabec133622
Aitkin129436
Watonwan12609
Rock123419
Jackson118210
Yellow Medicine111319
Pipestone110526
Pope10386
Murray10319
Swift100418
Marshall85817
Stevens83310
Lake78819
Clearwater78514
Koochiching77813
Wilkin77312
Lac qui Parle73922
Big Stone5764
Lincoln5613
Grant5528
Norman5229
Mahnomen5178
Unassigned48678
Kittson46822
Red Lake3877
Traverse3625
Lake of the Woods3073
Cook1480

Iowa Coronavirus Cases

Data is updated nightly.

Cases: 359450

Reported Deaths: 5839
CountyCasesDeaths
Polk56274608
Linn20392330
Scott19245236
Black Hawk15611306
Woodbury14960221
Johnson1415481
Dubuque13196203
Dallas1094596
Pottawattamie10804162
Story1035747
Warren559186
Clinton541791
Cerro Gordo524987
Webster508792
Sioux507873
Marshall477575
Muscatine463297
Des Moines443165
Wapello4255121
Buena Vista422140
Jasper408470
Plymouth398779
Lee369255
Marion355775
Jones293455
Henry286837
Carroll280152
Bremer279860
Crawford262840
Boone259633
Benton251155
Washington249850
Dickinson243743
Mahaska225750
Jackson218942
Kossuth213763
Clay212325
Tama206971
Delaware204539
Winneshiek194933
Page190721
Buchanan189031
Cedar185023
Fayette183541
Hardin181942
Wright180635
Hamilton178449
Harrison176673
Clayton167355
Butler162734
Mills159020
Cherokee157738
Floyd156242
Lyon155341
Madison154819
Poweshiek153233
Allamakee149351
Iowa146224
Hancock144234
Winnebago136931
Grundy135532
Cass135154
Calhoun133411
Jefferson131235
Emmet129940
Shelby129037
Sac128419
Louisa127349
Appanoose126747
Mitchell125441
Union123332
Chickasaw122715
Guthrie118529
Humboldt118426
Franklin113121
Palo Alto111323
Howard102922
Montgomery101537
Unassigned10040
Clarke98524
Keokuk95031
Monroe94528
Ida90133
Adair84832
Pocahontas84121
Monona81430
Davis79924
Osceola77116
Greene76710
Lucas75723
Worth7138
Taylor65412
Fremont6169
Decatur5919
Van Buren55518
Ringgold53624
Wayne52123
Audubon4969
Adams3314
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